Serum tumor marker, CA-125 has been investigated extensively for it's usefulness in the diagnosis and management of malignant ovarian tumors. However, the role of serum CA-125in the diagnosis and management of patients with borderline ovarian
tumors has
not beenestabl;ished. Retrospective analysis of serum CA-125 levels was performed in 15 patientsbefore operation and after treatment for borderline epithelial ovarian tumors at the Seoul Paik Hospital between 1989 and 1995.
@ES The results obtained were as follows:
@EN 1. The incidence of borderline malignant ovarian tumor among 69 cases of total group was 21.7%.
2. According to FIGO classification the patients were classified as : stage Ia(66.6%), stage Ib (6.7%), stage Ic(13.3%), stage IIc(6.7%), stage IIIa(6.7%).
3. The tumor sizes between patients with normal (less than 35 U/ml) and positive (over than 35 U/ml) of serum CA-125 were 15.43±5.06 cm ad 15.88±4.91 cm, respectively and there was no statistical difference between the two groups(p<0.05)
4. 100% of serous and 46.2 of mucinous tumors had elevated CA-125 levels, and there was no statistical difference between the two groups(p<0.05).
5. combining both cell types, 6(46.2%) of 13 patients with stage I disease and 2(100%) of 2 patients with stage II and III disease had positive preoperative levels. Serum CA-125 level was no statistical difference between the two
groups(p=0.467).
6. Serum CA-125 levels in patients with serous tumors (N=2) were after surgery from 259.00 U/ml to 152.23 U/ml(p=0.04), and with mucinous tumors (N=13) from 152.23 U/ml to 12.98 U/ml(p=0.04).
7. CA-125 levels in patients with positive CA-125 levels(N=8) were decreased after surgery from 294.57 U/ml to 18.01 U/ml (p=0.04), and with normal CA-125 level (N=7) from 7.61 U/ml to 5.25 U./ml(p=0.01).
8. Preoperative serum CA-125 levels in patients with malignant epithelial ovarian tumor were 372.85 U/ml, and wit borderline epithelial ovarian tumors were 166.47 U/ml, There was statistical difference between the two groups(p=0.006).
These data suggest that preoperative serum CA-125 level correlates with stage of disease and serum CA-125 levels decrease after surgery regardless the initial level before treatment.
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